Senior Research Scientist - Quantitative Systems Pharmacology

Company: Takeda Pharmaceutical
Location: Arlington
Posted on: May 14, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionSenior Research ScientistAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as Senior Research Scientist in our Cambridge, MA or San Diego, CA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.As a Senior Research Scientist working on the Quantitative Solutions team, you will be empowered to collaborate with preclinical research and drug discovery, DMPK, clinical pharmacology, clinical research, nonclinical drug safety, translational medicine and pharmacovigilance to develop mathematical models to understand the targeted biological pathways and exposure-response/safety relationship of novel therapeutic agentsA typical day will include:POSITION OBJECTIVES:

• The Mechanistic Modeler is responsible for supporting global drug development by building models for novel therapeutic agents to treat various gastrointestinal diseases including liver disease and diseases that result from abberant immune activation within the gut.
• Responsible for implementing the right modeling and simulation strategy to assist with drug development, establish PK/PD relationships and create mechanistic pharmacology/toxicology models to support project needs.
• Must have in-depth understanding of biochemistry, immunology, numerical methods, as well as hands-on experience with modeling software, and ability to clearly present modeling and simulation findings. -POSITION ACCOUNTABILITIES:
  • Interface between clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to influence drug development.
  • Design and build translational PK/PD and mechanistic or platforms models to assist with safety margin selection, study design and biomarker selection.EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
    • Ph.D/Pharm.D/M.D with training in chemical or biomedical engineering, pharmaceutical sciences, mathematics, statistics, or equivalent area with at least 3 years of industry experience in mathematical modeling of biological systems.
    • Job title is flexible based on experience.
    • Strong competency in coding and running modeling and simulation related software such as Matlab, NONMEM, Phoenix Winnonlin and R is required.
    • Publication(s) applying modeling and simulation approaches to gastrointestinal diseases and immunology is preferred.
    • Proficiency with systems modeling approaches such as differential equation, logic, stochastic, agent-based, or other advanced mechanistic modeling approaches is essential.
    • Demonstrated ability for critical thinking and strong analytical skills to evaluate complex information to identify key scientific questions related to projects.Takeda U.S. Vaccine Requirement:Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply. -TRAVEL REQUIREMENTS: WHAT TAKEDA CAN OFFER YOU:
      • 401(k) with company match and Annual Retirement Contribution Plan
      • Tuition reimbursement Company match of charitable contributions
      • Health & Wellness programs including onsite flu shots and health screenings
      • Generous time off for vacation and the option to purchase additional vacation days
      • Community Outreach ProgramsEmpowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.*KB-LIEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MASan Diego, CAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Arlington , Senior Research Scientist - Quantitative Systems Pharmacology, Other , Arlington, Massachusetts