Senior Scientist II, Precision Medicine TA

Company: AbbVie
Location: Waltham
Posted on: March 28, 2026

Job Description:

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description The Precision Medicine Department is committed to advancing drug development and patient care by deepening our understanding of disease biology and creating personalized treatment tools. Within the Precision Medicine Immunology group, our translational research teamutilizescutting-edgetechnologies to study immunology,identifybiomarkers, andvalidatedrug mechanisms across AbbVie's Immunology pipeline. We areseekinga highly motivated Senior Scientist II with a strong background in immunology or immune-oncology and a passion for translational research to join our team. This individual will lead the development of clinical biomarker strategies and assays for inflammatory and autoimmune diseasesincluding Dermatology, Gastroenterology, Rheumatology, and Fibrosisspanning late discovery through clinical trials. The successful candidate will collaborate within interdisciplinary teams, independently design and execute experiments, troubleshoot challenges, and interpret results to advance translational and biomarker research.Expertisein advanced molecular techniques, flow cytometry, and evaluation of drug target engagement, receptor occupancy, pharmacodynamics, as well as experience with human tissue and disease/drug biology, is essential for this role. Key Responsibilities: Lead biomarker strategies within cross-functional teams toidentifygaps and develop fit-for-purpose clinical TE/PD, predictive, and exploratory biomarker assays supporting human dose projection, early efficacy assessment, and patientselectionin clinical trials. Collaborate with Data Science and Precision Medicineleadsto analyze internal and external omics data, interpret disease heterogeneity/endotypes, and generate patient selection and combination hypotheses for preclinical studies. Develop preclinical, patient-derived disease models anddesign controlledstudies to elucidate drug target mechanisms, progress PD biomarker development, and assess biomarker and combination hypotheses. Serve as a subject matter expert in translational research methodologies, includingsingle-cell/spatial omics, proteomics,methylomics, metabolomics, genomics, NGS, MSD, ELISA, Luminex, flow cytometry, ex vivo and organoid culture. Provide training, troubleshoot assays, and introduce innovative technologies within AbbVie. Oversee external CROs and academic collaborations, managing study proposals, budgets, timelines, and data review. Manage and coach translational scientists to ensure successful execution of research plans across multiple projects. Stay current on advances in inflammatory and immune diseases through literature review, conferences, and consultation with KOLs. Qualifications Qualifications Major or advanced degree in Immunology, cell & molecular biology, pharmacology, pathology,bioinformaticsor other relevant biological sciences.B.S.ith12 years, M.S.with10 years, Ph.D.with4 years of relevant industrial biotechnology experience. Experience in leading translational medicine ingastrointestinal diseases(UC, CD) is a plus. Expertisein a broad range of translational technologies, dataanalyticsand computational tools. Proficient in multi-parameter flow cytometry, including spectral flow cytometry and analytical software (e.g., BDFACSDiva,Flowjo, OMIQ) to analyze different immune cell types and cell states from mice, human and cynomolgus monkey. Experienced in designing and conducting single cell omics, spatial omics, genomic-basedassaysand developing analytical workflow to generate orvalidatebiomarker hypotheses. Knowledgeable with integrative analysis of multi-dimensional datasets using bioinformatics tools and methods (e.g., R, Python, SQL, AI/ML, HPC and cloud environments) Strong project leadership and organizational skills to prioritize tasks andallocateresources to meet projects goals in a tight timeline. Experienced in managing CROs and collaborators,facilitatingmeetings, and working independently and collaboratively with multi-functional teams in a dynamic andfast pacedenvironment. Demonstrated ability to supervise and coach direct reports. Excellent communication, presentation, organizational and people management skills Strong track-record of scientific publications from peer reviewed journals and presentations in major conferences Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible toparticipatein our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Arlington , Senior Scientist II, Precision Medicine TA, Science, Research & Development , Waltham, Massachusetts